Failing to acknowledge God, to recognize Him for who He is, has a significant consequence: the mind will, not might, become depraved, reprobate, literally it will stop working on an intellectual level. The apostle Paul makes a startling declaration to support this in his letter to the Romans:
“And just as they did not see fit to acknowledge God, God gave them over to a depraved mind, to do what should not be done. (1:28)“
Knowledge of God has a curious effect, the mind opens and begins to struggle with issues that, to some people, are irrelevant to life. The mind focused on God sees more and farther than the mind focused on self. The risks become greater, the rewards more extravagant due to the goal being reached for. The mind focused on self, cares about nothing but what is immediate, self-satisfying, with no care for the consequences of their actions on their lives or the lives of others. When “self” is god, it must be worshipped at any cost, even if the cost is the mind itself, its ability to reason and be reasonable.
The depraved mind, as the Scripture says, focuses on things which ought not be done. These things are so horrific to think about that the apostle blazes through a list that compose the remaining verses of that chapter, but as we consider these verses, remember that they are merely symptoms of the problem (sin): failure to acknowledge God and give Him what is due Him.